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A 2025 study of 228,000 individuals with obesity, Type 2 diabetes, or alcohol use disorder, semaglutide and liraglutide use was associated with a 36% and 28% lower risk, respectively, of alcohol-related hospitalizations (such as intoxication and withdrawal symptoms) compared to patients who weren't prescribed GLP-1 medications (Lhteenvuo et al., 2025)

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10.29219/fnr.v67.10324 129 MylonaI.ToroM

Receptor profile: MT2 acts as a potent agonist at multiple melanocortin receptors, with primary activity at MC1R and MC4R and additional, weaker engagement of MC3R and MC5R, enabling simultaneous study of peripheral pigmentation and central neuroendocrine effects